Research Journal of Pharmacology and Pharmacodynamics

Jiban Debnath ¹, Santosh B. Dighe ², Nachiket S. Dighe ³, Supriya Mana ⁴

Affiliations
1 Department of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam, IN
2 Department of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, 413736, IN
3 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, IN
4 Department of Pharmacology, NSHM, College of Pharmaceutical Technology, Kolkata, IN

Abstract

In present study the anticonvulsant activity of ethanolic extract of Holarrhena antidysenterica was carried out in swiss albino mice. The anticonvulsant activity of ethanolic extract of seeds of Holarrhena antidysenterica (250 and 500 mg/kg, p.o.) in mice was assessed by using maximum electroshock seizure (MES) test, pentylenetetrazol (PTZ), and bicuculine (BC) test. The ethanolic extract of H. antidysenterica significantly reduced the duration of seizures induced by maximal electroshock (MES). The ethanol extract in doses of 250 and 500 mg/kg conferred protection (17 and 50%, respectively) on the mice. The same doses also protected animals from tonic seizures induced by Pentylenetetrazol and significantly delayed the onset of tonic seizures produced by Pentylenetetrazol. The extract had no effect on bicuculine induced seizure. The ethanolic extract of H. antidysenterica (EEHA) reduced MES, PTZ induced convulsions.

Keywords

Anticonvulsant, H. antidysenterica, MES, PTZ, BC.

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